General Information

  • ID:  hor007295
  • Uniprot ID:  Q9VT51??28-137)
  • Protein name:  Probable insulin-like peptide 2
  • Gene name:  NA
  • Organism:  Drosophila melanogaster
  • Family:  Insulin family
  • Source:  Human
  • Expression:  Broadly expressed at a low level in the embryonic mesoderm; beginning at stage 12. Expressed at a high level in the embryonic anterior midgut; with expression diminishing at late stage 16. Expressed a
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota (winged insects); Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae (pomace flies); Drosophilinae; Drosophilini; Drosophila (fruit flies); Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster (Fruit fly)
  • GO MF:  GO:0005576 extracellular region; GO:0005615 extracellular space
  • GO BP:  GO:0008083 growth factor activity; GO:0048018 receptor ligand activity; GO:0005158 insulin receptor binding; GO:0005179 hormone activity
  • GO CC:  GO:0042593 glucose homeostasis; GO:0060250 germ-line stem-cell niche homeostasis; GO:0045475 locomotor rhythm; GO:0008340 determination of adult lifespan; GO:0008286 insulin receptor signaling pathway; GO:0030536 larval feeding behavior; GO:0046622 positive regulation of organ growth; GO:0061964 negative regulation of entry into reproductive diapause; GO:0040018 positive regulation of multicellular organism growth; GO:0008361 regulation of cell size; GO:0040009 regulation of growth rate; GO:0040014 regulation of multicellular organism growth; GO:0045793 positive regulation of cell size; GO:0046620 regulation of organ growth; GO:1990928 response to amino acid starvation; GO:0071333 cellular response to glucose stimulus; GO:0032094 response to food; GO:0070328 triglyceride homeostasis; GO:0008284 positive regulation of cell population proliferation; GO:0030307 positive regulation of cell growth; GO:0045818 negative regulation of glycogen catabolic process; GO:0060180 female mating behavi

Sequence Information

  • Sequence:  LCSEKLNEVLSMVCEEYNPVIPHKRAMPGADSDLDALNPLQFVQEFEEEDNSISEPLRSALFPGSYLGGVLNSLAEVRRRTRQRQGIVERCCKKSCDMKALREYCSVVRN
  • Length:  110
  • Propeptide:  MSKPLSFISMVAVILLASSTVKLAQGTLCSEKLNEVLSMVCEEYNPVIPHKRAMPGADSDLDALNPLQFVQEFEEEDNSISEPLRSALFPGSYLGGVLNSLAEVRRRTRQRQGIVERCCKKSCDMKALREYCSVVRN
  • Signal peptide:  MSKPLSFISMVAVILLASSTVKLAQG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA